ABT-737
-AZZOTA
- C-1010
- Targets: PARP
- Synonym: ABT 737; ABT-737; ABT737
- Chemical Name/IUPAC:(R)-4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)benzamide
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Technical Data
- Product Name: ABT-737
- Chemical Formula: C42H45ClN6O5S2
- Molecular Weight: 813.43
- CAS#: 852808-04-9
- Appearance: Solid powder
- Purity: > 99% by HPLC
- Solubility: Soluble in DMSO
- Storage: Room temperature for six months, or -20oC for three years
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Description
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively. ABT-737 has no inhibition observed against Mcl-1, Bcl-B or Bfl-1.
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