AG-881 (Vorasidenib)

SKU: C-1090-5mg

Size:

5 mg

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Quantity

$206.99

Catalog#: C-1090
Targets: IDH1, IDH2
Synonym: AG-881; AG881; AG 881
Chemical Name/IUPAC:6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine
SMILES Code: C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F
Technical Data
Product Name: AG-881 (Vorasidenib)
Chemical Formula: C14H13ClF6N6
Molecular Weight: 414.74
CAS#: 1644545-52-7
Appearance: Solid powder
Purity: > 99% by HPLC
Solubility: Soluble in DMSO
Storage: Room temperature for one months, or -20ºC for three years

Description

AG-881 (Vorasidenib) is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations.