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Catalog#: C-1277 Qty: 5mg Targets: Proteasome Synonym: PR171; PR-171; PR 171; Carflizomib; Kyprolis Chemical Name/IUPAC:(S)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
Product Name: PR-171 (Carfilzomib) Chemical Formula: C40H57N5O7 Molecular Weight: 719.91 CAS#: 868540-17-4 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
PR-171 (Carfilzomib) is an irreversible proteasome inhibitor. PR-171 irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.