SKU: C-1277-5mg
C40H57N5O7 Solid Powder
$49.99
  • Catalog#: C-1277
  • Targets: Proteasome
  • Synonym: PR171; PR-171; PR 171; Carflizomib; Kyprolis
  • Chemical Name/IUPAC:(S)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
    Technical Data
  • Product Name: PR-171 (Carfilzomib)
  • Chemical Formula: C40H57N5O7
  • Molecular Weight: 719.91
  • CAS#: 868540-17-4
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    PR-171 (Carfilzomib) is an irreversible proteasome inhibitor. PR-171 irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.