PR-171 (Carfilzomib)
-Technical Data
Description
PR-171 (Carfilzomib) is an irreversible proteasome inhibitor. PR-171 irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.