PLX-3397 (Pexidartinib)

SKU: C-1271-10mg

Quantity (mg):

10 mg

Product Options

Quantity

$73.99

Catalog#: C-1271

Targets: KIT, FLT3, CSF1R

Synonym: PLX3397; PLX-3397; PLX 3397; Pexidartinib

Chemical Name/IUPAC:5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

SMILES Code: FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F

Technical Data

Product Name: PLX-3397 (Pexidartinib)

Chemical Formula: C20H15ClF3N5

Molecular Weight: 417.81

CAS#: 1029044-16-3

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
PLX-3397 (Pexidartinib) is a small-molecule receptor tyrosine kinase inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease.

PLX-3397 (Pexidartinib)

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