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Catalog#: C-1271 Qty: 5mg Targets: KIT, FLT3, CSF1R Synonym: PLX3397; PLX-3397; PLX 3397; Pexidartinib Chemical Name/IUPAC:5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine SMILES Code: FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
Product Name: PLX-3397 (Pexidartinib) Chemical Formula: C20H15ClF3N5 Molecular Weight: 417.81 CAS#: 1029044-16-3 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
PLX-3397 (Pexidartinib) is a small-molecule receptor tyrosine kinase inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease.