SKU: C-1271-10mg
 C20H15ClF3N5 Solid Powder
  • Catalog#: C-1271
  • Targets: KIT, FLT3, CSF1R
  • Synonym: PLX3397; PLX-3397; PLX 3397; Pexidartinib
  • Chemical Name/IUPAC:5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
  • SMILES Code: FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
    Technical Data
  • Product Name: PLX-3397 (Pexidartinib)
  • Chemical Formula: C20H15ClF3N5
  • Molecular Weight: 417.81
  • CAS#: 1029044-16-3
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    PLX-3397 (Pexidartinib) is a small-molecule receptor tyrosine kinase inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease.