MK-1775 (AZD-1775)
-![MK-1775 (AZD-1775) Chemical Formula: C27H32N8O2 solid powder](http://labshops.com/cdn/shop/products/C-1223_272x272.jpg?v=1560194998)
Technical Data
Description
MK-1775 (AZD-1775) is a WEE1 inhibitor. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.