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Catalog#: C-1223 Quantity: 5mg Targets: WEE1 Synonym: MK-1775; MK1775; MK 1775; AZD1775; AZD-1775; AZD 1775 Chemical Name/IUPAC:2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
Product Name: MK-1775 (AZD-1775) Chemical Formula: C27H32N8O2 Molecular Weight: 500.59 CAS#: 955365-80-7 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
MK-1775 (AZD-1775) is a WEE1 inhibitor. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.