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Catalog#: C-1147 Quantity: 5mg Targets: PI3K Synonym: GDC-0941; GDC 0941; GDC0941; RG7321; RG-7321; RG 7321; GNE0941; GNE-0941; GNE 0941; Pictrelisib; Pictilisib Chemical Name/IUPAC:4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine
Product Name: GDC-0941 Chemical Formula: C23H27N7O3S2 Molecular Weight: 513.63 CAS#: 957054-30-7 (free base); 957054-33-0 (mesylate) Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GDC-0941 is an orally bioavailable, and is a potent PI3K isoforms p100alpha and p100delta with potential antineoplastic activity. GDC-0941 selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway; inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations may result.