SKU: C-1133-5mg
EPZ-5676 (Pinometostat)
  • Catalog#: C-1133
  • Quantity: 5mg
  • Targets: Histone Methyltransferase
  • Synonym: EPZ5676; EPZ-5676; EPZ 5676; Pinometostat
  • Chemical Name/IUPAC:(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
    Technical Data
  • Product Name: EPZ-5676 (Pinometostat)
  • Chemical Formula: C30H42N8O3
  • Molecular Weight: 562.7
  • CAS#: 1380288-87-8
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    EPZ-5676 (Pinometostat) is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes.