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Catalog#: C-1133 Quantity: 5mg Targets: Histone Methyltransferase Synonym: EPZ5676; EPZ-5676; EPZ 5676; Pinometostat Chemical Name/IUPAC:(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
Product Name: EPZ-5676 (Pinometostat) Chemical Formula: C30H42N8O3 Molecular Weight: 562.7 CAS#: 1380288-87-8 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
EPZ-5676 (Pinometostat) is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes.