SKU: C-1084-5mg
C18H21F3N6O2 BKM-120(Buparlisib) solid powder
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  • Catalog#: C-1084
  • Targets: PI3K
  • Synonym: NVPBKM120; NVP BKM120; NV- BKM120; BKM120; BKM-120; BKM 120; Buparlisib
  • Chemical Name/IUPAC:5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine
    Technical Data
  • Product Name: BKM-120 (Buparlisib)
  • Chemical Formula: C18H21F3N6O2
  • Molecular Weight: 410.39
  • CAS#: 944396-07-0 (free base)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    BKM-120 (Buparlisib) is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity. BKM-120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway.