PR-171 (Carfilzomib)

SKU: C-1277-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$57.99

Catalog#: C-1277

Targets: Proteasome

Synonym: PR171; PR-171; PR 171; Carflizomib; Kyprolis

Chemical Name/IUPAC:(S)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Technical Data

Product Name: PR-171 (Carfilzomib)

Chemical Formula: C40H57N5O7

Molecular Weight: 719.91

CAS#: 868540-17-4

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
PR-171 (Carfilzomib) is an irreversible proteasome inhibitor. PR-171 irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

PR-171 (Carfilzomib)

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