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Catalog#: C-1429 Quantity: 5mg Targets: Proteasome Synonym: MG-132; MG132; MG 132 Chemical Name/IUPAC:benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate SMILES Code: O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C=O)=O)=O
Product Name: MG-132 Chemical Formula: C26H41N3O5 Molecular Weight: 475.62 CAS#: 133407-82-6 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
MG-132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG-132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG-132 also inhibits NF-?B activation with an IC50 of 3 µM and prevents ?-secretase cleavage. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway.