TPX-0005

SKU: C-1409-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$137.99

Catalog#: C-1409

Targets: ALK; ROS1; TRK

Synonym: TPX-0005; TPX0005; TPX 0005

Chemical Name/IUPAC:(13E,14E,3R,6S)-45-fluoro-3,6-dimethyl-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphan-9-one

SMILES Code: FC1=CC([C@@H](C)NC2=NC3=C4C=NN3C=C2)=C(O[C@@H](C)CNC4=O)C=C1

Technical Data

Product Name: TPX-0005

Chemical Formula: C18H18FN5O2

Molecular Weight: 355.37

CAS#: 1802220-02-5

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
TPX-0005 is a potent ALK/ROS1/TRK inhibitor. TPX-0005 effectively inhibited a broad spectrum of mutations including solvent front ALK G1202R, ROS1 G2032R and TRKA G595R mutants. TPX-0005 potently inhibited WT ALK (IC50 1.01 nM) and mutant ALKs including ALK G1202R (1.26 nM) and ALK L1196M (1.08 nM). Moreover, TPX-0005 effectively inhibited tumor growth in vivo in ALK WT and ALK G1202R xenografts. TPX-0005 is also a potent SRC inhibitor (IC50 5.3 nM).

TPX-0005

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