SKU: C-1409-5mg
TPX-0005 Chemical Formula: C18H18FN5O2
  • Catalog#: C-1409
  • Targets: ALK; ROS1; TRK
  • Synonym: TPX-0005; TPX0005; TPX 0005
  • Chemical Name/IUPAC:(13E,14E,3R,6S)-45-fluoro-3,6-dimethyl-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphan-9-one
  • SMILES Code: FC1=CC([C@@H](C)NC2=NC3=C4C=NN3C=C2)=C(O[C@@H](C)CNC4=O)C=C1
    Technical Data
  • Product Name: TPX-0005
  • Chemical Formula: C18H18FN5O2
  • Molecular Weight: 355.37
  • CAS#: 1802220-02-5
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    TPX-0005 is a potent ALK/ROS1/TRK inhibitor. TPX-0005 effectively inhibited a broad spectrum of mutations including solvent front ALK G1202R, ROS1 G2032R and TRKA G595R mutants. TPX-0005 potently inhibited WT ALK (IC50 1.01 nM) and mutant ALKs including ALK G1202R (1.26 nM) and ALK L1196M (1.08 nM). Moreover, TPX-0005 effectively inhibited tumor growth in vivo in ALK WT and ALK G1202R xenografts. TPX-0005 is also a potent SRC inhibitor (IC50 5.3 nM).