ON-123300
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Technical Data
Description
ON-123300 is a potent multikinase inhibitor of ARK5 and CDK4, as well as growth factor receptor tyrosine kinases such as ?-type platelet-derived growth factor receptor (PDGFR?). ON-123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 ?mol/L. ON-123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo.