ON-123300

SKU: C-1403-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$172.99

Catalog#: C-1403

Targets: ARK5 ; CDK4

Synonym: ON-123300; ON 123300; ON123300

Chemical Name/IUPAC:8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile

SMILES Code: N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O

Technical Data

Product Name: ON-123300

Chemical Formula: C24H27N7O

Molecular Weight: 429.53

CAS#: 1357470-29-1

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
ON-123300 is a potent multikinase inhibitor of ARK5 and CDK4, as well as growth factor receptor tyrosine kinases such as ?-type platelet-derived growth factor receptor (PDGFR?). ON-123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 ?mol/L. ON-123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo.

ON-123300

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