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Catalog#: C-1403 Quantity: 5mg Targets: ARK5 ; CDK4 Synonym: ON-123300; ON 123300; ON123300 Chemical Name/IUPAC:8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile SMILES Code: N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O
Product Name: ON-123300 Chemical Formula: C24H27N7O Molecular Weight: 429.53 CAS#: 1357470-29-1 Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
ON-123300 is a potent multikinase inhibitor of ARK5 and CDK4, as well as growth factor receptor tyrosine kinases such as ?-type platelet-derived growth factor receptor (PDGFR?). ON-123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 ?mol/L. ON-123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo.