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ON-123300

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SKU: C-1403-5mg
ON-123300 Chemical Formula: C24H27N7O Solid Powder
$150.00
  • Made in USA, High-Purity Standard Quality
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  • Catalog#: C-1403
  • Quantity: 5mg
  • Targets: ARK5 ; CDK4
  • Synonym: ON-123300; ON 123300; ON123300
  • Chemical Name/IUPAC:8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
  • SMILES Code: N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O
    Technical Data
  • Product Name: ON-123300
  • Chemical Formula: C24H27N7O
  • Molecular Weight: 429.53
  • CAS#: 1357470-29-1
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    ON-123300 is a potent multikinase inhibitor of ARK5 and CDK4, as well as growth factor receptor tyrosine kinases such as ?-type platelet-derived growth factor receptor (PDGFR?). ON-123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 ?mol/L. ON-123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo.


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