SKU: C-1392-5mg
CPI-444 Chemical Formula: C20H21N7O3  Solid Powder
  • Catalog#: C-1392
  • Targets: A2A
  • Synonym: CPI-444; CPI444; CPI 444
    Technical Data
  • Product Name: CPI-444
  • Chemical Formula: C20H21N7O3
  • Molecular Weight: 407.43
  • CAS#: 1202402-40-1
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    CPI-444 is a small molecule immune checkpoint inhibitor of the adenosine A2A receptor (ADORA2A) with potential antineoplastic activity. Upon oral administration, adenosine-A2A receptor antagonist CPI-444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor-released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine-induced immunosuppression in the tumor microenvironment. This may stimulate anti-tumor immune responses, resulting in tumor regression.