H3B-6527

SKU: C-1373-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$129.99

Catalog#: C-1373

Targets: FGFR4

Synonym: H3B-6527; H3B6527; H3B 6527

Chemical Name/IUPAC:N-{2-[(6-{[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}-4-pyrimidinyl)amino]-5-(4-ethyl-1-piperazinyl)phenyl}acrylamide

SMILES Code: C=CC(NC1=CC(N2CCN(CC)CC2)=CC=C1NC3=NC=NC(N(C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)C)=C3)=O

Technical Data

Product Name: H3B-6527

Chemical Formula: C29H34Cl2N8O4

Molecular Weight: 629.54

CAS#: 1702259-66-2

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
H3B-6527 is a potent, selective and orally bioavailable inhibitor of human FGFR4 (fibroblast growth factor receptor 4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.

H3B-6527

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