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H3B-6527

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SKU: C-1373
H3B-6527
$190.00
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  • Catalog#: C-1373
  • Quantity: 5mg
  • Targets: FGFR4
  • Synonym: H3B-6527; H3B6527; H3B 6527
  • Chemical Name/IUPAC:N-{2-[(6-{[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}-4-pyrimidinyl)amino]-5-(4-ethyl-1-piperazinyl)phenyl}acrylamide
  • SMILES Code: C=CC(NC1=CC(N2CCN(CC)CC2)=CC=C1NC3=NC=NC(N(C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)C)=C3)=O
    Technical Data
  • Product Name: H3B-6527
  • Chemical Formula: C29H34Cl2N8O4
  • Molecular Weight: 629.54
  • CAS#: 1702259-66-2
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    H3B-6527 is a potent, selective and orally bioavailable inhibitor of human FGFR4 (fibroblast growth factor receptor 4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.


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