GSK-2830371

SKU: C-1372

Made in USA, High-Purity Standard Quality

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Catalog#: C-1372

Quantity: 5mg

Targets: Wip1

Synonym: GSK-2830371 ; GSK2830371 ; GSK 2830371

Technical Data

Product Name: GSK-2830371

Chemical Formula: C23H29ClN4O2S

Molecular Weight: 461.02

CAS#: 1404456-53-6

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
GSK-2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). GSK-2830371 exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also, GSK-2830371 inhibits lymphoma xenograft growth in vivo.

GSK-2830371

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