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Catalog#: C-1372 Quantity: 5mg Targets: Wip1 Synonym: GSK-2830371 ; GSK2830371 ; GSK 2830371
Product Name: GSK-2830371 Chemical Formula: C23H29ClN4O2S Molecular Weight: 461.02 CAS#: 1404456-53-6 Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GSK-2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). GSK-2830371 exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also, GSK-2830371 inhibits lymphoma xenograft growth in vivo.