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GSK-2830371

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SKU: C-1372-5mg
GSK-2830371 Chemical Formula: C23H29ClN4O2S Solid Powder
$90.00
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  • Catalog#: C-1372
  • Quantity: 5mg
  • Targets: Wip1
  • Synonym: GSK-2830371 ; GSK2830371 ; GSK 2830371
    Technical Data
  • Product Name: GSK-2830371
  • Chemical Formula: C23H29ClN4O2S
  • Molecular Weight: 461.02
  • CAS#: 1404456-53-6
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    GSK-2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). GSK-2830371 exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also, GSK-2830371 inhibits lymphoma xenograft growth in vivo.


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