LY-3009120 (DP-4978) is potent and selective pan-RAF inhibitor with potential anticancer activity. LY-3009120 showed activities against BRaf or Ras mutant tumor cells. LY-3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY-3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY-3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas.