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Catalog#: C-1355 Quantity: 5mg Targets: RAF Synonym: LY-3009120; LY3009120; LY 3009120; DP4978; DP 4978; DP-4978 Chemical Name/IUPAC:1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea
Product Name: LY-3009120 (DP-4978) Chemical Formula: C23H29FN6O Molecular Weight: 424.52 CAS#: 1454682-72-4 Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
LY-3009120 (DP-4978) is potent and selective pan-RAF inhibitor with potential anticancer activity. LY-3009120 showed activities against BRaf or Ras mutant tumor cells. LY-3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY-3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY-3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas.