SKU: C-1321-5mg
 Tubastatin A Chemical Formula: C20H21N3O2
  • Catalog#: C-1321
  • Targets: HDAC
  • Synonym: Tubastatin A
  • Chemical Name/IUPAC:N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide
    Technical Data
  • Product Name: Tubastatin A
  • Chemical Formula: C20H21N3O2
  • Molecular Weight: 335.4
  • CAS#: 1252003-15-8 (free base)
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 ?M), excluding HDAC8 (IC50= 0.9 ?M). Tubastatin A induces ?-tubulin hyperacetylation at 2.5 ?M in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 ?M.