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Catalog#: C-1321 Quantity: 5mg Targets: HDAC Synonym: Tubastatin A Chemical Name/IUPAC:N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide
Product Name: Tubastatin A Chemical Formula: C20H21N3O2 Molecular Weight: 335.4 CAS#: 1252003-15-8 (free base) Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 ?M), excluding HDAC8 (IC50= 0.9 ?M). Tubastatin A induces ?-tubulin hyperacetylation at 2.5 ?M in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 ?M.