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TKI-258 (Dovitinib)

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SKU: C-1317-5mg
TKI-258 (Dovitinib) Chemical Formula: C24H27FN6O4
$57.99
  • Catalog#: C-1317
  • Targets: FHFR
  • Synonym: TKI258; TKI-258; TKI 258; CHIR258; CHIR-258; CHIR 258; Dovitinib lactate
  • Chemical Name/IUPAC:4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate
    Technical Data
  • Product Name: TKI-258 (Dovitinib)
  • Chemical Formula: C24H27FN6O4
  • Molecular Weight: 482.51
  • CAS#: 915769-50-5 (lactate); 405169-16-6 (free base)
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    TKI-258 (Dovitinib) is an orally bioavailable FGFR3 inhibitor, which strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death.


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