SKU: C-1301-5mg
 C20H22F3N5O Solid Powder
  • Catalog#: C-1301
  • Targets: PIM
  • Synonym: SGI1776; SGI-1776; SGI 1776
  • Chemical Name/IUPAC:N-((1-methylpiperidin-4-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine
    Technical Data
  • Product Name: SGI-1776
  • Chemical Formula: C20H22F3N5O
  • Molecular Weight: 405.42
  • CAS#: 1025065-69-3
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.