SCH-900776 (MK-8776)
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Technical Data
Description
SCH-900776 (MK-8776) is a potent inhibitor of Chk1 (checkpoint kinase 1 ) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH-900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.