SKU: C-1300-5mg
C15H18BrN7 Solid Powder
$80.00
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  • Catalog#: C-1300
  • Quantity: 5mg
  • Targets: Chk
  • Synonym: SCH900776; SCH-900776; SCH 900776; MK8776; MK-8776; MK 8776
  • Chemical Name/IUPAC:(R)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
    Technical Data
  • Product Name: SCH-900776 (MK-8776)
  • Chemical Formula: C15H18BrN7
  • Molecular Weight: 376.25
  • CAS#: 891494-63-6
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    SCH-900776 (MK-8776) is a potent inhibitor of Chk1 (checkpoint kinase 1 ) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH-900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.