SCH-900776 (MK-8776)

SKU: C-1300-5mg

Size:

5 mg

Product Options

Quantity

$80.00

Made in USA, High-Purity Standard Quality

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Catalog#: C-1300

Quantity: 5mg

Targets: Chk

Synonym: SCH900776; SCH-900776; SCH 900776; MK8776; MK-8776; MK 8776

Chemical Name/IUPAC:(R)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine

Technical Data

Product Name: SCH-900776 (MK-8776)

Chemical Formula: C15H18BrN7

Molecular Weight: 376.25

CAS#: 891494-63-6

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
SCH-900776 (MK-8776) is a potent inhibitor of Chk1 (checkpoint kinase 1 ) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH-900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

SCH-900776 (MK-8776)

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