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Catalog#: C-1300 Quantity: 5mg Targets: Chk Synonym: SCH900776; SCH-900776; SCH 900776; MK8776; MK-8776; MK 8776 Chemical Name/IUPAC:(R)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Product Name: SCH-900776 (MK-8776) Chemical Formula: C15H18BrN7 Molecular Weight: 376.25 CAS#: 891494-63-6 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
SCH-900776 (MK-8776) is a potent inhibitor of Chk1 (checkpoint kinase 1 ) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH-900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.