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Rocaglamide

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SKU: C-1292-2mg
Rocaglamide C29H31NO7 Solid Powder
$349.99
  • Catalog#: C-1292
  • Targets: NF-?B
  • Synonym: Rocaglamide; Rocaglamide A; RocA; NSC 326408
  • Chemical Name/IUPAC:(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
    Technical Data
  • Product Name: Rocaglamide
  • Chemical Formula: C29H31NO7
  • Molecular Weight: 505.56
  • CAS#: 84573-16-0
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    Rocaglamide is an immunosuppressant, and a potent inhibitor of NF-?B activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-?, TNF-?, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-?B and AP-1 activities.


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