Rocaglamide

SKU: C-1292-2mg

Quantity (mg):

2 mg

Product Options

Quantity

$402.99

Catalog#: C-1292

Targets: NF-?B

Synonym: Rocaglamide; Rocaglamide A; RocA; NSC 326408

Chemical Name/IUPAC:(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide

Technical Data

Product Name: Rocaglamide

Chemical Formula: C29H31NO7

Molecular Weight: 505.56

CAS#: 84573-16-0

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
Rocaglamide is an immunosuppressant, and a potent inhibitor of NF-?B activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-?, TNF-?, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-?B and AP-1 activities.

Rocaglamide

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