PLX-4032 (Vemurafenib)

SKU: C-1272

Made in USA, High-Purity Standard Quality

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Catalog#: C-1272

Qty: 5mg

Targets: RAF

Synonym: PLX4032; PLX 4032; PLX-4032; RG7204 ; RG7204 ; RG 7204 ; RO5185426; RO 5185426 RO5185426 Vemurafenib; Zelboraf

Chemical Name/IUPAC:N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Technical Data

Product Name: PLX-4032 (Vemurafenib)

Chemical Formula: C23H18ClF2N3O3S

Molecular Weight: 489.92

CAS#: 918504-65-1

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
PLX-4032 (Vemurafenib) is an orally bioavailable, ATP-competitive, small-molecule inhibitor of B-Raf(V600E) kinase with potential antineoplastic activity. PLX-4032 selectively binds to the ATP-binding site of B-Raf(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in B-Raf(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation.

PLX-4032 (Vemurafenib)

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