PLX-4032 (Vemurafenib)
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Technical Data
Description
PLX-4032 (Vemurafenib) is an orally bioavailable, ATP-competitive, small-molecule inhibitor of B-Raf(V600E) kinase with potential antineoplastic activity. PLX-4032 selectively binds to the ATP-binding site of B-Raf(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in B-Raf(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation.