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Catalog#: C-1272 Qty: 5mg Targets: RAF Synonym: PLX4032; PLX 4032; PLX-4032; RG7204 ; RG7204 ; RG 7204 ; RO5185426; RO 5185426 RO5185426 Vemurafenib; Zelboraf Chemical Name/IUPAC:N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Product Name: PLX-4032 (Vemurafenib) Chemical Formula: C23H18ClF2N3O3S Molecular Weight: 489.92 CAS#: 918504-65-1 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
PLX-4032 (Vemurafenib) is an orally bioavailable, ATP-competitive, small-molecule inhibitor of B-Raf(V600E) kinase with potential antineoplastic activity. PLX-4032 selectively binds to the ATP-binding site of B-Raf(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in B-Raf(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation.