SKU: C-1269-5mg
Chemical Formula: C35H30N4O4 Solid Powder
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  • Catalog#: C-1269
  • Qty: 5mg
  • Targets: PKC
  • Synonym: PKC-412; PKC412; PKC 412; PKC412A; PKC-412A; PKC 412A; CGP41251; CGP 41251; CGP-41251; Midostaurin
  • Chemical Name/IUPAC:N-((5R,7R,8R,9S)-8-methoxy-9-methyl-16-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide
    Technical Data
  • Product Name: PKC-412 (Midostaurin)
  • Chemical Formula: C35H30N4O4
  • Molecular Weight: 570.63
  • CAS#: 120685-11-2
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    PKC-412 (Midostaurin) is a synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. PKC-412 inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.