SKU: C-1266-5mg
PF-4989216 Chemical Formula: C18H13FN6OS Solid Powder
  • Catalog#: C-1266
  • Targets: PI3K
  • Synonym: PF4989216; PF 4989216; PF-4989216
  • Chemical Name/IUPAC:4-(4-cyano-2-fluorophenyl)-2-morpholino-5-(1H-1,2,4-triazol-5-yl)thiophene-3-carbonitrile
    Technical Data
  • Product Name: PF-4989216
  • Chemical Formula: C18H13FN6OS
  • Molecular Weight: 380.39
  • CAS#: 1276553-09-3
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.