Made in USA, High-Purity Standard Quality We offer a low price guarantee to ensure that you always get your penny's worth. If you find a lower price on an identical item within 7 days of your purchase from another US competitor, contact us and we'll price match! Same day FREE shipping, if the item is in stock!
Catalog#: C-1266 Qty: 5mg Targets: PI3K Synonym: PF4989216; PF 4989216; PF-4989216 Chemical Name/IUPAC:4-(4-cyano-2-fluorophenyl)-2-morpholino-5-(1H-1,2,4-triazol-5-yl)thiophene-3-carbonitrile
Product Name: PF-4989216 Chemical Formula: C18H13FN6OS Molecular Weight: 380.39 CAS#: 1276553-09-3 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.