PF-4989216

SKU: C-1266-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$91.99

Catalog#: C-1266

Targets: PI3K

Synonym: PF4989216; PF 4989216; PF-4989216

Chemical Name/IUPAC:4-(4-cyano-2-fluorophenyl)-2-morpholino-5-(1H-1,2,4-triazol-5-yl)thiophene-3-carbonitrile

Technical Data

Product Name: PF-4989216

Chemical Formula: C18H13FN6OS

Molecular Weight: 380.39

CAS#: 1276553-09-3

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.

PF-4989216

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