SKU: C-1263-5mg
 PF-06747775 Chemical Formula: C18H22FN9O2 Solid Powder
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  • Catalog#: C-1263
  • Quantity: 5mg
  • Targets: EGFR
  • Synonym: PF06747775; PF06747775; PF 06747775; PF6747775; PF 6747775; PF6747775
  • Chemical Name/IUPAC:N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide
    Technical Data
  • Product Name: PF-06747775
  • Chemical Formula: C18H22FN9O2
  • Molecular Weight: 415.43
  • CAS#: 1776112-90-3
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    PF-06747775 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M inhibitor PF-06747775 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.