PF-06747775

SKU: C-1263-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$91.99

Catalog#: C-1263

Targets: EGFR

Synonym: PF06747775; PF06747775; PF 06747775; PF6747775; PF 6747775; PF6747775

Chemical Name/IUPAC:N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide

Technical Data

Product Name: PF-06747775

Chemical Formula: C18H22FN9O2

Molecular Weight: 415.43

CAS#: 1776112-90-3

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
PF-06747775 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M inhibitor PF-06747775 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.

PF-06747775

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