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Catalog#: C-1263 Quantity: 5mg Targets: EGFR Synonym: PF06747775; PF06747775; PF 06747775; PF6747775; PF 6747775; PF6747775 Chemical Name/IUPAC:N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide
Product Name: PF-06747775 Chemical Formula: C18H22FN9O2 Molecular Weight: 415.43 CAS#: 1776112-90-3 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
PF-06747775 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M inhibitor PF-06747775 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.