PF-04554878 (Defactinib)

SKU: C-1256

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Catalog#: C-1256

Quantity: 5mg

Targets: FAK

Synonym: VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878; Defactinib

Chemical Name/IUPAC:N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

Technical Data

Product Name: PF-04554878 (Defactinib)

Chemical Formula: C20H21F3N8O3S

Molecular Weight: 510.49

CAS#: 1073154-85-4 (free base)

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
PF-04554878 (Defactinib) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival.

PF-04554878 (Defactinib)

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