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PF-04554878 (Defactinib)

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SKU: C-1256-5mg
PF-04554878 (Defactinib) Chemical Formula: C20H21F3N8O3S Solid Powder
$91.99
  • Catalog#: C-1256
  • Targets: FAK
  • Synonym: VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878; Defactinib
  • Chemical Name/IUPAC:N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide
    Technical Data
  • Product Name: PF-04554878 (Defactinib)
  • Chemical Formula: C20H21F3N8O3S
  • Molecular Weight: 510.49
  • CAS#: 1073154-85-4 (free base)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    PF-04554878 (Defactinib) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival.


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