SKU: C-1254-5mg
 PF-04217903 Chemical Formula: C19H16N8O Solid Powder
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  • Catalog#: C-1254
  • Quantity: 5mg
  • Targets: c-Met
  • Synonym: PF04217903; PF 04217903; PF-04217903; PF4217903; PF-4217903; PF 4217903
  • Chemical Name/IUPAC:2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol
    Technical Data
  • Product Name: PF-04217903
  • Chemical Formula: C19H16N8O
  • Molecular Weight: 372.38
  • CAS#: 956905-27-4 (free base); 956906-93-7 (mesylate)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    PF-04217903 is also an orally bioavailabe, small-molecule tyrosine kinase inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met.