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Catalog#: C-1254 Quantity: 5mg Targets: c-Met Synonym: PF04217903; PF 04217903; PF-04217903; PF4217903; PF-4217903; PF 4217903 Chemical Name/IUPAC:2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol
Product Name: PF-04217903 Chemical Formula: C19H16N8O Molecular Weight: 372.38 CAS#: 956905-27-4 (free base); 956906-93-7 (mesylate) Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
PF-04217903 is also an orally bioavailabe, small-molecule tyrosine kinase inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met.