Home / Collections / CHEMICALS / PD-0332991 (Palbociclib)

PD-0332991 (Palbociclib)

-
SKU: C-1250
PD-0332991 (Palbociclib)
$40.00
  • Made in USA, High-Purity Standard Quality
  • We offer a low price guarantee to ensure that you always get your penny's worth. If you find a lower price on an identical item within 7 days of your purchase from another US competitor, contact us and we'll price match!
  • Same day FREE shipping, if the item is in stock!

  • Catalog#: C-1250
  • Quantity: 5mg
  • Targets: CDK
  • Synonym: PD-0332991; PD 0332991; PD0332991; Palbociclib free base; Ibrance.
  • Chemical Name/IUPAC:6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
    Technical Data
  • Product Name: PD-0332991 (Palbociclib)
  • Chemical Formula: C24H29N7O2
  • Molecular Weight: 447.54
  • CAS#: 571190-30-2 (free base)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    PD-0332991 (Palbociclib) is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.


    • Related products

    MEK-162 (ARRY-162)

    -

    MEK-162 (ARRY-162)

    from $60.00

    E-7090

    -

    E-7090

    from $280.00

    E-7080 (Lenvatinib Mesylate)

    -

    E-7080 (Lenvatinib Mesylate)

    $250.00

    E-7046

    -

    E-7046

    $250.00