PD-0332991 (Palbociclib)

SKU: C-1250-10mg

Quantity (mg):

10 mg

Product Options

Quantity

$78.99

Catalog#: C-1250

Targets: CDK

Synonym: PD-0332991; PD 0332991; PD0332991; Palbociclib free base; Ibrance.

Chemical Name/IUPAC:6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Technical Data

Product Name: PD-0332991 (Palbociclib)

Chemical Formula: C24H29N7O2

Molecular Weight: 447.54

CAS#: 571190-30-2 (free base)

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
PD-0332991 (Palbociclib) is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.

PD-0332991 (Palbociclib)

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