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Catalog#: C-1250 Quantity: 5mg Targets: CDK Synonym: PD-0332991; PD 0332991; PD0332991; Palbociclib free base; Ibrance. Chemical Name/IUPAC:6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
Product Name: PD-0332991 (Palbociclib) Chemical Formula: C24H29N7O2 Molecular Weight: 447.54 CAS#: 571190-30-2 (free base) Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
PD-0332991 (Palbociclib) is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.