SKU: C-1245-5mg
OSI-906 (Linsitinib) Chemical Formula: C26H23N5O Solid Powder
  • Catalog#: C-1245
  • Targets: IGFR
  • Synonym: OSI906; OSI-906; OSI 906; Linsitinib
  • Chemical Name/IUPAC:(1r,3r)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol
    Technical Data
  • Product Name: OSI-906 (Linsitinib)
  • Chemical Formula: C26H23N5O
  • Molecular Weight: 421.5
  • CAS#: 867160-71-2
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    OSI-906 (Linsitinib) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.