LDE-225 (Sonidegib)

SKU: C-1242-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$91.99

Catalog#: C-1242

Targets: Smoothened

Synonym: LDE225; LDE 225; LDE-225; NVP-LDE225; NVP-LDE-225; NVP LDE225; Erismodegib; Sonidegib; Odomzo

Chemical Name/IUPAC:N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide

Technical Data

Product Name: LDE-225 (Sonidegib)

Chemical Formula: C26H26F3N3O3

Molecular Weight: 485.49

CAS#: 956697-53-3 (free base)

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
LDE-225 (Sonidegib) is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. LDE-225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated.

LDE-225 (Sonidegib)

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