SKU: C-1242-5mg
LDE-225 (Sonidegib)
  • Catalog#: C-1242
  • Targets: Smoothened
  • Synonym: LDE225; LDE 225; LDE-225; NVP-LDE225; NVP-LDE-225; NVP LDE225; Erismodegib; Sonidegib; Odomzo
  • Chemical Name/IUPAC:N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
    Technical Data
  • Product Name: LDE-225 (Sonidegib)
  • Chemical Formula: C26H26F3N3O3
  • Molecular Weight: 485.49
  • CAS#: 956697-53-3 (free base)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    LDE-225 (Sonidegib) is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. LDE-225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated.