LDE-225 (Sonidegib)
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Technical Data
Description
LDE-225 (Sonidegib) is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. LDE-225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated.