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Catalog#: C-1230 Quantity: 5mg Targets: RAF Synonym: TAK-580; TAK 580; TAK580; MLN 2480; MLN-2480; MLN2480; BIIB024, BIIB 024, BIIB-024; AMG 2112819; AMG2112819; AMG-2112819 Chemical Name/IUPAC:(R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide
Product Name: MLN-2480 Chemical Formula: C17H12Cl2F3N7O2S Molecular Weight: 506.29 CAS#: 1096708-71-2 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
MLN2480 is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.