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MGCD-516 (Sitravatinib)

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SKU: C-1217-5mg
MGCD-516 (Sitravatinib) Chemical Formula: C33H29F2N5O4S
$80.00
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  • Catalog#: C-1217
  • Quantity: 5mg
  • Targets: RTKs
  • Synonym: MGCD516; MGCD-516; MGCD 516; MG516; MG 516; MG-516; Sitravatinib
  • Chemical Name/IUPAC:N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    Technical Data
  • Product Name: MGCD-516 (Sitravatinib)
  • Chemical Formula: C33H29F2N5O4S
  • Molecular Weight: 629.68
  • CAS#: 1123837-84-2
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    MGCD-516 (Sitravatinib) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. MGCD-516 treatment resulted in significant blockade of phosphorylation of potential driver RTKs and induced potent anti-proliferative effects in vitro. MGCD-516 treatment of tumor xenografts in vivo resulted in significant suppression of tumor growth.


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