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Catalog#: C-1217 Quantity: 5mg Targets: RTKs Synonym: MGCD516; MGCD-516; MGCD 516; MG516; MG 516; MG-516; Sitravatinib Chemical Name/IUPAC:N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Product Name: MGCD-516 (Sitravatinib) Chemical Formula: C33H29F2N5O4S Molecular Weight: 629.68 CAS#: 1123837-84-2 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
MGCD-516 (Sitravatinib) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. MGCD-516 treatment resulted in significant blockade of phosphorylation of potential driver RTKs and induced potent anti-proliferative effects in vitro. MGCD-516 treatment of tumor xenografts in vivo resulted in significant suppression of tumor growth.