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Catalog#: C-1206 Quantity: 5mg Targets: FGFR Synonym: LY2874455; LY 2874455; LY-2874455 Chemical Name/IUPAC:(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol
Product Name: LY-2874455 Chemical Formula: C21H19Cl2N5O2 Molecular Weight: 444.31 CAS#: 1254473-64-7 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
LY-2874455 is a novel and potent pan-FGFR inhibitor. It exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship.