LY-2835219 (Abemaciclib)

SKU: C-1205-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$68.99

Catalog#: C-1205

Targets: CDK

Synonym: LY2835219; LY2835219; LY 2835219; Abemaciclib

Chemical Name/IUPAC:N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

Technical Data

Product Name: LY-2835219 (Abemaciclib)

Chemical Formula: C27H32F2N8

Molecular Weight: 506.59

CAS#: 1231929-97-7 (free base)

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
LY-2835219 (Abemaciclib) is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY-2835219 specifically inhibits CDK4/6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

LY-2835219 (Abemaciclib)

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