LY-2801653 (Merestinib)
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Technical Data
Description
LY-2801653 (Merestinib) is an orally available, small molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor LY-2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.