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LY-2801653 (Merestinib)

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SKU: C-1204-5mg
LY-2801653 (Merestinib) Chemical Formula: C30H22F2N6O3 Solid Powder
$149.99
  • Catalog#: C-1204
  • Targets: c-Met
  • Synonym: LY-2801653; LY 2801653; LY2801653; Merestinib
  • Chemical Name/IUPAC:N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
    Technical Data
  • Product Name: LY-2801653 (Merestinib)
  • Chemical Formula: C30H22F2N6O3
  • Molecular Weight: 552.53
  • CAS#: 1206799-15-6 (free base); 1206801-37-7 (HCl)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    LY-2801653 (Merestinib) is an orally available, small molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor LY-2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.


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