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Catalog#: C-1204 Quantity: 5mg Targets: c-Met Synonym: LY-2801653; LY 2801653; LY2801653; Merestinib Chemical Name/IUPAC:N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Product Name: LY-2801653 (Merestinib) Chemical Formula: C30H22F2N6O3 Molecular Weight: 552.53 CAS#: 1206799-15-6 (free base); 1206801-37-7 (HCl) Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
LY-2801653 (Merestinib) is an orally available, small molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor LY-2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.