SKU: C-1198-5mg
LEE-011 (Ribociclib) Chemical Formula: C23H30N8O
  • Catalog#: C-1198
  • Targets: CDK
  • Synonym: LEE011; LEE-011. LEE 011; Ribociclib
  • Chemical Name/IUPAC:7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
    Technical Data
  • Product Name: LEE-011 (Ribociclib)
  • Chemical Formula: C23H30N8O
  • Molecular Weight: 434.54
  • CAS#: 1211441-98-3 (free base)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    LEE-011 (Ribociclib) is a n orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.