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Catalog#: C-1196 Quantity: 5mg Targets: SMAC Synonym: LCL161; LCL 161; LCL-161 Chemical Name/IUPAC:(S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
Product Name: LCL-161 Chemical Formula: C26H33FN4O3S Molecular Weight: 500.63 CAS#: 1005342-46-0 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
LCL-161 is a n orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL-161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2.