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Catalog#: C-1190 Quantity: 5mg Targets: FGFR Synonym: JNJ-42756493; JNJ 42756493; JNJ42756493; Erdafitinib Chemical Name/IUPAC:N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine
Product Name: JNJ-42756493 (Erdafitinib) Chemical Formula: C25H30N6O2 Molecular Weight: 446.55 CAS#: 1346242-81-6 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
JNJ-42756493 (Erdafitinib) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.