SKU: C-1190
JNJ-42756493 (Erdafitinib)
$90.00
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  • Catalog#: C-1190
  • Quantity: 5mg
  • Targets: FGFR
  • Synonym: JNJ-42756493; JNJ 42756493; JNJ42756493; Erdafitinib
  • Chemical Name/IUPAC:N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine
    Technical Data
  • Product Name: JNJ-42756493 (Erdafitinib)
  • Chemical Formula: C25H30N6O2
  • Molecular Weight: 446.55
  • CAS#: 1346242-81-6
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    JNJ-42756493 (Erdafitinib) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.