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Catalog#: C-1187 Quantity: 5mg Targets: Hedgehog Synonym: IPI 926; IPI-926; IPI926; Saridegib Chemical Name/IUPAC:N-((2S,3R,3aS,3'R,4a'R,6S,6a'R,6b'S,7aR,12a'S,12b'S)-3,6,11',12b'-tetramethyl-2',3a,3',4,4',4a',5,5',6,6',6a',6b',7,7a,7',8',10',12',12a',12b'-icosahydro-1'H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide
Product Name: IPI-926 (Saridegib) Chemical Formula: C29H48N2O3S Molecular Weight: 504.76 CAS#: 1037210-93-7 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
IPI-926 (Saridegib) is an orally bioavailable inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.