SKU: C-1184
IPI-145 (INK-1197, Duvelisib)
$70.00
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  • Catalog#: C-1184
  • Quantity: 5mg
  • Targets: PI3K
  • Synonym: IPI145; IPI 145; IPI-145. INK1197; INK 1197; INK-1197; Duvelisib
  • Chemical Name/IUPAC:(S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one
    Technical Data
  • Product Name: IPI-145 (INK-1197, Duvelisib)
  • Chemical Formula:
  • CAS#: 1201438-56-3
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    IPI-145 (INK-1197, Duvelisib) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases.