SKU: C-1183
INK-128 (Sapanisertib) Chemical Formula: C15H15N7O Solid Powder
$70.00
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  • Catalog#: C-1183
  • Quantity: 5mg
  • Targets: mTOR
  • Synonym: INK128; INK-128; INK 128; MLN0128; MLN 0128; MLN-0128; Sapanisertib
  • Chemical Name/IUPAC:3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
    Technical Data
  • Product Name: INK-128 (Sapanisertib)
  • Chemical Formula: C15H15N7O
  • Molecular Weight: 309.33
  • CAS#: 1224844-38-5
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    INK-128 (Sapanisertib) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.