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INCB-024360 (Epacadostat)

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SKU: C-1180-5mg
INCB-024360 (Epacadostat) Chemical Formula: C11H13BrFN7O4S Solid Water
$59.99
  • Catalog#: C-1180
  • Targets: IDO
  • Synonym: INCB024360; INCB 024360; INCB-024360; INCB24360; INCB-24360; INCB 24360; Epacadostat
  • Chemical Name/IUPAC:(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide
    Technical Data
  • Product Name: INCB-024360 (Epacadostat)
  • Chemical Formula: C11H13BrFN7O4S
  • Molecular Weight: 438.23
  • CAS#: 1204669-58-8
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    INCB-024360 (Epacadostat) is an orally available inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB-024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB-024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells.


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