SKU: C-1178-5mg
INCB-018424 (Ruxolitinib)
  • Catalog#: C-1178
  • Targets: JAK
  • Synonym: INCB018424; INCB 018424; INCB-018424; INC424; IN C424; INC-424; INCB18424; INCB 18424; INCB-18424; Jakafi; Jakavi
  • Chemical Name/IUPAC:(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
    Technical Data
  • Product Name: INCB-018424 (Ruxolitinib)
  • Chemical Formula: C17H18N6
  • Molecular Weight: 306.37
  • CAS#: 941678-49-5 (free base)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    INCB-018424 (Ruxolitinib) is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. INCB-018424 specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation.