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Catalog#: C-1178 Quantity: 5mg Targets: JAK Synonym: INCB018424; INCB 018424; INCB-018424; INC424; IN C424; INC-424; INCB18424; INCB 18424; INCB-18424; Jakafi; Jakavi Chemical Name/IUPAC:(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Product Name: INCB-018424 (Ruxolitinib) Chemical Formula: C17H18N6 Molecular Weight: 306.37 CAS#: 941678-49-5 (free base) Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
INCB-018424 (Ruxolitinib) is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. INCB-018424 specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation.