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GSK-525762 (I-BET-762)

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SKU: C-1171-5mg
GSK-525762 (I-BET-762) Chemical Formula: C22H22ClN5O2 Solid Powder
$91.99
  • Catalog#: C-1171
  • Targets: BET
  • Synonym: GSK525762; GSK525762; GSK525762; GSK525762A; GSK525762A; GSK 525762A; IBET762; IBET762; IBET 762; molibresib
  • Chemical Name/IUPAC:(S)-2-(6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
    Technical Data
  • Product Name: GSK-525762 (I-BET-762)
  • Chemical Formula: C22H22ClN5O2
  • Molecular Weight: 423.9
  • CAS#: 1260907-17-2
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    GSK-525762 (I-BET-762) is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK-525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth.


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