GSK-2606414

SKU: C-1167-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$91.99

Catalog#: C-1167

Targets: PERK

Synonym: GSK2606414; GSK-2606414; GSK 2606414

Chemical Name/IUPAC:1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone

Technical Data

Product Name: GSK-2606414

Chemical Formula: C24H20F3N5O

Molecular Weight: 451.44

CAS#: 1337531-36-8

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
GSK-2606414 is an orally available, potent, and selective PERK inhibitor. GSK-2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small molecule inhibitors.

GSK-2606414

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