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GSK-2606414

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SKU: C-1167-5mg
GSK-2606414 Chemical Formula: C24H20F3N5O Solid Powder
$91.99
  • Catalog#: C-1167
  • Targets: PERK
  • Synonym: GSK2606414; GSK-2606414; GSK 2606414
  • Chemical Name/IUPAC:1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone
    Technical Data
  • Product Name: GSK-2606414
  • Chemical Formula: C24H20F3N5O
  • Molecular Weight: 451.44
  • CAS#: 1337531-36-8
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    GSK-2606414 is an orally available, potent, and selective PERK inhibitor. GSK-2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small molecule inhibitors.


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