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Catalog#: C-1164 Quantity: 5mg Targets: AKT Synonym: GSK2141795; GSK2141795; GSK 2141795; GSK795; GSK795; GSK 795; Uprosertib Chemical Name/IUPAC:N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
Product Name: GSK-2141795 (Uprosertib) Chemical Formula: C18H16Cl2F2N4O2 Molecular Weight: 429.25 CAS#: 1047634-65-0 (free base) Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GSK-2141795 (Uprosertib) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.