Made in USA, High-Purity Standard Quality We offer a low price guarantee to ensure that you always get your penny's worth. If you find a lower price on an identical item within 7 days of your purchase from another US competitor, contact us and we'll price match! Same day FREE shipping, if the item is in stock!
Catalog#: C-1158 Quantity: 5mg Targets: EZH2 Synonym: GSK2816126; GSK-2816126; GSK 2816126; GSK-126; GSK126; GSK-126 Chemical Name/IUPAC:(S)-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
Product Name: GSK-126 Chemical Formula: C31H38N6O2 Molecular Weight: 526.67 CAS#: 1346574-57-9 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GSK-126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK-126 decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK-126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.