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Catalog#: C-1156 Quantity: 5mg Targets: MEK Synonym: GSK 1120212 GSK1120212; GSK-1120212; JTP74057; Trametinib; Mekinist Chemical Name/IUPAC:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
Product Name: GSK-1120212 (Trametinib) Chemical Formula: C26H23FIN5O4 Molecular Weight: 615.39 CAS#: 871700-17-3 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GSK-1120212 (Trametinib) is a n orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK) with potential antineoplastic activity. GSK-1120212 specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth.