GKT-137831
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Technical Data
Description
GKT-137831 is a novel and potent Nox4 inhibitor. GKT-137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT-137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT-137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.
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