Made in USA, High-Purity Standard Quality We offer a low price guarantee to ensure that you always get your penny's worth. If you find a lower price on an identical item within 7 days of your purchase from another US competitor, contact us and we'll price match! Same day FREE shipping, if the item is in stock!
Catalog#: C-1151 Quantity: 5mg Targets: Nox4 Synonym: GKT137831; GKT-137831; GKT 137831; GTK831; GTK-831; GTK 831 Chemical Name/IUPAC:2-(2-chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione
Product Name: GKT-137831 Chemical Formula: C21H19ClN4O2 Molecular Weight: 394.85 CAS#: 1218942-37-0 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GKT-137831 is a novel and potent Nox4 inhibitor. GKT-137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT-137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT-137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.