SKU: C-1151
GKT-137831
$100.00
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  • Catalog#: C-1151
  • Quantity: 5mg
  • Targets: Nox4
  • Synonym: GKT137831; GKT-137831; GKT 137831; GTK831; GTK-831; GTK 831
  • Chemical Name/IUPAC:2-(2-chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione
    Technical Data
  • Product Name: GKT-137831
  • Chemical Formula: C21H19ClN4O2
  • Molecular Weight: 394.85
  • CAS#: 1218942-37-0
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    GKT-137831 is a novel and potent Nox4 inhibitor. GKT-137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT-137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT-137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.