GKT-137831

SKU: C-1151-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$114.99

Catalog#: C-1151

Targets: Nox4

Synonym: GKT137831; GKT-137831; GKT 137831; GTK831; GTK-831; GTK 831

Chemical Name/IUPAC:2-(2-chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione

Technical Data

Product Name: GKT-137831

Chemical Formula: C21H19ClN4O2

Molecular Weight: 394.85

CAS#: 1218942-37-0

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
GKT-137831 is a novel and potent Nox4 inhibitor. GKT-137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT-137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT-137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.

GKT-137831

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