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GDC-0994 (Ravoxertinib)

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SKU: C-1150-5mg
GDC-0994 (Ravoxertinib) Chemical Formula: C21H18ClFN6O2 Solid Powder
$80.00
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  • Catalog#: C-1150
  • Quantity: 5mg
  • Targets: ERK
  • Synonym: GDC0994; GDC-0994; GDC 0994; RG7842; RG-7842; RG 7842; Ravoxertinib
  • Chemical Name/IUPAC:(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
    Technical Data
  • Product Name: GDC-0994 (Ravoxertinib)
  • Chemical Formula: C21H18ClFN6O2
  • Molecular Weight: 440.86
  • CAS#: 1453848-26-4
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    GDC-0994 (Ravoxertinib) is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.


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